Recipe Cajun Chicken Alfredo: Creamy & Spicy Delight

Updated On: October 15, 2025

If you’re craving a dish that combines bold spices with creamy indulgence, our Cajun Chicken Alfredo recipe is exactly what you need. This mouthwatering dish brings together tender, juicy chicken breasts seasoned with a vibrant Cajun spice blend, nestled atop a bed of perfectly cooked fettuccine pasta and smothered in a rich, velvety Alfredo sauce.

It’s comfort food with a kick, perfect for a weeknight dinner or a special gathering. The spicy Cajun seasoning contrasts beautifully with the creamy, cheesy sauce, creating a harmonious balance that will have your taste buds dancing.

Not only is this recipe delicious, but it’s also straightforward enough for cooks of all skill levels. Whether you’re a seasoned chef or a kitchen newbie, you’ll find this dish rewarding to make and even more satisfying to eat.

So, grab your skillet and let’s dive into this flavorful Cajun Chicken Alfredo that’s sure to become a new favorite in your dinner rotation!

Why You’ll Love This Recipe

This Cajun Chicken Alfredo recipe is a delightful twist on a classic Italian favorite. Here’s why it stands out:

  • Bold flavors: The Cajun seasoning infuses the chicken with smoky, spicy notes that elevate the creamy Alfredo sauce.
  • Comforting and creamy: The rich Alfredo sauce made with butter, cream, and Parmesan cheese offers a velvety texture that’s pure indulgence.
  • Quick and easy: Ready in under 40 minutes, this dish is perfect for busy weeknights or last-minute guests.
  • Customizable: You can add veggies like bell peppers or mushrooms or swap out the pasta for zoodles or gluten-free options.
  • Family-friendly: Kids and adults alike will love the creamy sauce paired with flavorful chicken.

Ingredients

  • 2 boneless, skinless chicken breasts, sliced into strips
  • 2 tablespoons Cajun seasoning (store-bought or homemade)
  • 12 ounces fettuccine pasta
  • 3 tablespoons unsalted butter
  • 4 cloves garlic, minced
  • 2 cups heavy cream
  • 1 cup freshly grated Parmesan cheese
  • Salt and freshly ground black pepper, to taste
  • 2 tablespoons olive oil
  • Fresh parsley, chopped (for garnish)
  • Optional: red pepper flakes for extra heat

Equipment

  • Large pot for boiling pasta
  • Large skillet or frying pan
  • Wooden spoon or spatula
  • Chef’s knife
  • Cutting board
  • Measuring cups and spoons
  • Colander for draining pasta
  • Grater for Parmesan cheese

Instructions

  1. Prepare the chicken: Pat the chicken strips dry with paper towels. Sprinkle the Cajun seasoning evenly over both sides, pressing gently so it adheres well.
  2. Cook the pasta: Bring a large pot of salted water to a boil. Add the fettuccine and cook according to package instructions until al dente. Reserve 1/2 cup of pasta water, then drain the pasta and set aside.
  3. Sear the chicken: Heat the olive oil in a large skillet over medium-high heat. Add the Cajun-seasoned chicken strips and cook for 4-5 minutes per side, or until the chicken is cooked through and has a nice sear. Remove chicken from the skillet and set aside.
  4. Make the Alfredo sauce: In the same skillet, reduce heat to medium and add the butter. Once melted, add the minced garlic and sauté for about 1 minute until fragrant but not browned.
  5. Add cream and cheese: Slowly pour in the heavy cream, stirring constantly. Allow it to simmer gently for 3-4 minutes to thicken. Then, gradually whisk in the Parmesan cheese until the sauce is smooth and creamy.
  6. Adjust seasoning: Taste the sauce and season with salt, black pepper, and red pepper flakes if you desire extra heat. If the sauce is too thick, add a splash of the reserved pasta water to loosen it up.
  7. Combine pasta and sauce: Add the cooked fettuccine to the skillet, tossing gently to coat the pasta evenly with Alfredo sauce.
  8. Add chicken: Return the Cajun chicken strips to the skillet, mixing everything together so the chicken is nestled in the creamy sauce.
  9. Garnish and serve: Sprinkle chopped fresh parsley over the top and serve immediately. Enjoy your spicy, creamy Cajun Chicken Alfredo!

Tips & Variations

For a lighter version, swap heavy cream with half-and-half or whole milk, but keep in mind the sauce will be less thick and creamy.

  • Make it vegetarian: Substitute the chicken with sautéed mushrooms or your favorite plant-based protein.
  • Add veggies: Toss in sliced bell peppers, spinach, or sun-dried tomatoes for extra color and nutrients.
  • Spice level: Adjust the Cajun seasoning and red pepper flakes to your preferred heat level.
  • Homemade Cajun seasoning: Mix paprika, cayenne, garlic powder, onion powder, oregano, thyme, salt, and black pepper to create your own blend.
  • Cheese choice: Use Pecorino Romano or a mix of Parmesan and Asiago for a richer flavor profile.

Nutrition Facts

Nutrient Amount per Serving
Calories 720 kcal
Protein 45 g
Carbohydrates 50 g
Fat 35 g
Saturated Fat 18 g
Cholesterol 150 mg
Sodium 680 mg
Fiber 2 g

Serving Suggestions

This Cajun Chicken Alfredo pairs wonderfully with simple sides that complement its rich flavors. Here are some ideas:

Conclusion

Cajun Chicken Alfredo is a perfect fusion of spicy and creamy, bringing a delightful twist to a beloved classic. This recipe is not only packed with bold Cajun flavors but also offers a luscious Alfredo sauce that’s irresistibly smooth and cheesy.

It’s a versatile dish that can be customized with your favorite vegetables or plant-based options, making it suitable for a variety of dietary preferences.

Whether you’re cooking for a family dinner, date night, or just craving something special, this recipe delivers satisfaction in every bite. For more delicious recipes to add to your culinary repertoire, check out our collection of Afghan Vegetarian Pulao Recipe Easy and Delicious Guide and Vegan Recipes No Tofu: Delicious Plant-Based Meals.

Happy cooking and bon appétit!

📖 Recipe Card: Cajun Chicken Alfredo

Description: A creamy Alfredo pasta dish with spicy Cajun-seasoned chicken. Perfectly balanced flavors for a hearty meal.

Prep Time: PT15M
Cook Time: PT20M
Total Time: PT35M

Servings: 4 servings

Ingredients

  • 2 boneless, skinless chicken breasts
  • 2 tablespoons Cajun seasoning
  • 8 ounces fettuccine pasta
  • 2 tablespoons olive oil
  • 3 cloves garlic, minced
  • 1 cup heavy cream
  • 1 cup grated Parmesan cheese
  • 2 tablespoons unsalted butter
  • Salt and pepper to taste
  • Chopped parsley for garnish

Instructions

  1. Season chicken breasts with Cajun seasoning.
  2. Cook pasta according to package instructions; drain and set aside.
  3. Heat olive oil in a skillet over medium heat.
  4. Cook chicken until golden and cooked through, about 6-7 minutes per side; remove and slice.
  5. In the same skillet, melt butter and sauté garlic until fragrant.
  6. Add heavy cream and bring to a simmer.
  7. Stir in Parmesan cheese until sauce thickens.
  8. Add cooked pasta and sliced chicken to the sauce; toss to combine.
  9. Season with salt and pepper as needed.
  10. Garnish with chopped parsley and serve warm.

Nutrition: Calories: 650 kcal | Protein: 45 g | Fat: 38 g | Carbs: 35 g

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Marta K

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